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. 2022 May 24;8:50. doi: 10.1038/s41421-022-00412-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic illustration of 5-HT receptors coupling to distinct G proteins upon stimulation by 5-HT and 5-CT. 5-HT₁ and 5-HT₅ belong to G_i/o-coupled 5-HT receptors. 5-HT₁ subfamily includes 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT_1E, and 5-HT_1F. Different from other 5-HT receptor subtypes, 5-HT₃ is an ion channel. b, c Orthogonal views of the density map (b) and model (c) for the 5-CT–5-HT_5A–G_i–scFv16 complex. The EM density of 5-CT is shown as cyan surface presentation. d The extracellular view of the 5-HT_5A. The complex is colored by subunits. Light pink, 5-HT_5A; cyan, 5-CT; blue, Gα_i; salmon, Gβ; light green, Gγ; light blue, scFv16.