Table 2.
Genetic risk | Total no. of participants | No. of lung cancer cases (%) | Person-years | IRa | Model 1b | Model 2c | Model 3d | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HR (95% CI) | P value | P for trend | HR (95% CI) | P value | P for trend | HR (95% CI) | P value | P for trend | |||||
Low | 69,155 | 248 (0.36) | 491,385 | 0.50 | 1 (reference) | <0.001 | 1 (reference) | <0.001 | 1 (reference) | <0.001 | |||
Intermediate | 207,465 | 1019 (0.49) | 1,472,759 | 0.69 | 1.39 (1.21–1.60) | <0.001 | 1.40 (1.22–1.61) | <0.001 | 1.38 (1.20–1.58) | <0.001 | |||
High | 69,174 | 420 (0.61) | 490771 | 0.86 | 1.73 (1.48–2.03) | <0.001 | 1.73 (1.48–2.02) | <0.001 | 1.69 (1.44–1.97) | <0.001 | |||
per SD increase | 1.16 (1.11–1.22) | 1.41 × 10−10 | – | 1.16 (1.11–1.22) | 1.35 × 10−10 | – | 1.16 (1.10–1.21) | 9.64 × 10−10 | – |
IR incidence rate, HR hazard ratio, CI confidence interval, SD standard deviation.
aIncidence rates are provided per 1000 person-years.
bModel 1: Cox proportional hazards regression adjusted for age, sex, education, Townsend deprivation index, income, BMI, diet, physical activity, alcohol consumption, occupational exposure, passive smoking, relatedness and first 20 principal components of ancestry; P value for trend calculated treating the polygenic risk score as a continuous variable.
cModel 2: Cox proportional hazards regression adjusted for Model 1 and smoking status categories; P value for trend calculated treating the genetic-risk score as a continuous variable.
dModel 3: Cox proportional hazards regression adjusted for Model 1 and smoking pack-years categories; P value for trend calculated treating the genetic-risk score as a continuous variable.