Table 2.

Risk of incident lung cancer according to genetic risk.

Genetic risk	Total no. of participants	No. of lung cancer cases (%)	Person-years	IRa	Model 1b			Model 2c			Model 3d
					HR (95% CI)	P value	P for trend	HR (95% CI)	P value	P for trend	HR (95% CI)	P value	P for trend
Low	69,155	248 (0.36)	491,385	0.50	1 (reference)		<0.001	1 (reference)		<0.001	1 (reference)		<0.001
Intermediate	207,465	1019 (0.49)	1,472,759	0.69	1.39 (1.21–1.60)	<0.001		1.40 (1.22–1.61)	<0.001		1.38 (1.20–1.58)	<0.001
High	69,174	420 (0.61)	490771	0.86	1.73 (1.48–2.03)	<0.001		1.73 (1.48–2.02)	<0.001		1.69 (1.44–1.97)	<0.001
per SD increase					1.16 (1.11–1.22)	1.41 × 10−10	–	1.16 (1.11–1.22)	1.35 × 10−10	–	1.16 (1.10–1.21)	9.64 × 10−10	–

IR incidence rate, HR hazard ratio, CI confidence interval, SD standard deviation.

^aIncidence rates are provided per 1000 person-years.

^bModel 1: Cox proportional hazards regression adjusted for age, sex, education, Townsend deprivation index, income, BMI, diet, physical activity, alcohol consumption, occupational exposure, passive smoking, relatedness and first 20 principal components of ancestry; P value for trend calculated treating the polygenic risk score as a continuous variable.

^cModel 2: Cox proportional hazards regression adjusted for Model 1 and smoking status categories; P value for trend calculated treating the genetic-risk score as a continuous variable.

^dModel 3: Cox proportional hazards regression adjusted for Model 1 and smoking pack-years categories; P value for trend calculated treating the genetic-risk score as a continuous variable.