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. 2022 May 24;13:2899. doi: 10.1038/s41467-022-30625-9

Fig. 7. Schematic model depicting the role of ANO1-mediated osteoclast differentiation and function.

Fig. 7

Under RANKL stimulation, the interaction between Ano1 and RANK was enhanced, and RANK downstream signaling pathways was activated, which promoted the Ano1 channel activity and enhanced its interaction with RANK.