Fig. 4.

Exosomes-incorporated F127-HA hydrogels promote chondrocytes proliferation, migration and differentiation. A Chondrocytes proliferation at day 1, 4 and 7. B, C Calcein AM/PI staining and survival rates of chondrocytes at day 3. The green signal represents live cells, whereas the red signal represents dead cells. D, E Transwell test and quantitative analysis of cell migration. F–I RT-qPCR analysis of chondrogenic-related genes Runx1, Sox9, Aggrecan, and COL2a1 in chondrocytes after chondrogenic induction for 14 days (*p < 0.05, **p < 0.01)