Table 4.

Cox regression results of incidence of DKD for the latent class of serum Cysc.

	Model 1		Model 2		Model 3
Latent class	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Low-increasing	Reference		Reference		Reference
Middle-increasing	1.44 (1.06, 1.98)	0.019	1.70 (1.18, 2.44)	0.004	1.80 (1.17, 2.77)	0.007
High-increasing	1.45 (0.87, 2.403)	0.158	2.12 (1.22, 3.68)	0.008	3.43 (1.93, 6.11)	<0.001

Model 1, unadjusted by other variables.

Model 2, adjusted for baseline age, gender, and duration.

Model 3, adjusted for baseline age, gender, DM duration, smoker, HbA1c, TC, TG, urea, UA and AST. TG and urea are time-dependent covariances.