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. 2022 May 11;16:856734. doi: 10.3389/fncel.2022.856734

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Copyright © 2022 Ulrichsen, Gonçalves, Mohseni, Hjæresen, Lisle, Molgaard, Madsen, Andersen, Svenningsen, Glerup, Nykjær and Vægter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduced axon ensheathment by Remak Schwann cells in regenerated Sort1^–^/^– sciatic nerve. Significantly more partially enclosed C-fibers were observed in the injured Sort1^–^/^– sciatic nerve compared to WT. Representative images showing normal Schwann cell ensheathment of C-fibers in injured WT sciatic nerve 25 days after crush injury (indicated by the green arrow) and only partly enclosure of C-fibers by Schwann cell cytoplasm and partly by only basement membrane 25 days after sciatic nerve crush injury in WT (green stars) and the Sort1^–^/^– mouse (indicated by red stars and red arrows). Scale bars: left images 2 μm, right images (zoom of left) 1 μm. (A,B) N = 6 WT mice and 6 Sort1^–^/^– mice. Statistical significance was established with two-way ANOVA and Bonferroni’s multiple comparisons post hoc test (***p < 0.001).