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. 2022 May 11;9:897815. doi: 10.3389/fcvm.2022.897815

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Copyright © 2022 Chen, Tian, Wang, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of GSDMD in canonical inflammasome activation. The canonical pathway of pyroptosis. PAMPs or DAMPs bind to inflammasome to activate caspase-1, cleaving GSDMD to form GSDMD-C and GSDMD-N. GSDMD-N cluster and bind to the plasma membrane to form GSDMD pores. Simultaneously activated caspase-1 activates IL-18 and IL-1β, and cytokines IL-18 and IL-1β are released into the cell through the GSDMD pore. In addition to IL-18 and IL-1β, HMGB1 is also removed.