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. 2022 May 11;9:897815. doi: 10.3389/fcvm.2022.897815

FIGURE 2.

FIGURE 2

Role of GSDMD in non-canonical inflammasome activation. The canonical pathway of pyroptosis. When LPS enters cells, it directly participates in and activates human caspase-4 and caspase-5 and mouse caspase-11. Caspase-11 cleaves GSDMD, forming GSDMD-C and GSDMD-N. GSDMD-N cluster and bind to the plasma membrane. Formation of GSDMD pore, the formation of GSDMD pore activates inflammasome to bind to caspase-1, activated caspase-1 activates IL-18 and IL-1β, and cytokines IL-18 and IL-1β are released extracellularly through GSDMD pore.