TABLE 1.

Characteristics of GSDM family proteins.

Gene	Activate way	Organism	Disease links	References
GSDMA	Autoactive	Human and mouse	Alopecia	(71)
GSDMB	GzmA Caspase-4	Human	Autoimmune disease, breast cancer, asthma, uterine cervix cancer, tumor	(43, 45, 46, 72)
GSDMC	Caspase-8	Human and mouse	Tumor, colorectal cancer	(49, 51)
GSDMD	Caspase-1/4/5/11	Human and mouse	Autoimmune encephalomyelitis, Yersinia infection, familial Mediterranean	(25, 73, 74)
GSDME	Autoactive Caspase-3 GzmB	Human and mouse	Tumor, hearing impairment	(29, 53, 66)
GSDMF	Not known	Human and mouse	Auditory neuropathy	(75)