TABLE 2.

Key information of caspase family.

Caspase	Organism	Type	Biological function	References
Caspase-1	Human and mouse	Cytokine Activators	Pyroptosis	(80)
Caspase-2	Human and mouse	Initiator Caspases	RCD	(81)
Caspase-3	Human and mouse	Executioner Caspases	Apoptosis/pyroptosis	(64, 82)
Caspase-4	Human	Cytokine Activators	Pyroptosis	(21, 83)
Caspase-5	Human	Cytokine Activators	Pyroptosis	(11, 83)
Caspase-6	Human and mouse	Executioner Caspases	Apoptotic/pyroptosis	(84)
Caspase-7	Human and mouse	Executioner Caspases	Apoptotic	(85)
Caspase-8	Human and mouse	Initiator Caspases	Necroptosis/pyroptosis	(86–89)
Caspase-9	Human and mouse	Initiator Caspases	RCD	(85)
Caspase-10	Human and mouse	Initiator Caspases	RCD	(90)
Caspase-11	Mouse	Cytokine Activators	Pyroptosis	(21, 22, 91)
Caspase-12	Mouse	Not known	RCD	(92, 93)
Caspase-14	Human and mouse	Executioner Caspases	Unknown	(94–96)