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. 2022 May 11;13:874021. doi: 10.3389/fimmu.2022.874021

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Copyright © 2022 Yang, Xiang, Zou, Zhang, Ni and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cross-correlation analysis between microbiota and metabolites. (A, B) Heatmap of the correlation between the top 28 OTUs with statistical difference annotated at the genus level and metabolites in the ESI- and ESI+ ion modes. (C, D) Heatmap of the correlation between the three microbiotas in genus level and metabolites in the ESI- and ESI+ ion modes. The horizontal coordinate represents the differentially abundant bacteria at the level of the 16S gene, and the vertical coordinate represents the differentially abundant metabolites. Red indicates a positive correlation, blue indicates a negative correlation, and an asterisk (*) indicates statistical significance, that is, P < 0.05. (E–H) Scatter plot of the correlation between Escherichia-Shigella and four metabolites (aflatoxin M1, glycocholic acid, L-histidine and phenylglyoxylic acid).