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. 2022 May 11;10:887100. doi: 10.3389/fcell.2022.887100

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Copyright © 2022 Dreyer, VanderVorst and Carraway.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Establishment of planar cell polarity. Planar cell polarity (PCP) is the organization of cells across a tissue plane orthogonal to the apical-basal axis. PCP is established through asymmetric distribution of core component complexes, where Vangl-Pk and Fzd-Dvl complexes localize to opposite sides of the cell. Cell polarity is maintained and propagated to neighboring cells through intercellular protein-protein interactions between opposing complexes, and homophilic interactions between Fmi/Celsr.