TABLE 2.
Correlation between FANCD2 levels and markers of immune cells based on TIMER and GEPIA databases.
Cell type | Gene marker | None | Purity | Tumor | Normal | ||||
---|---|---|---|---|---|---|---|---|---|
Cor | P | Cor | P | R | P | R | P | ||
B cell | CD19 | −0.003 | 0.9410 | 0.004 | 0.9210 | −0.085 | 0.063 | 0.41 | 0.0011** |
CD20(KRT20) | 0.027 | 0.5440 | 0.021 | 0.6440 | 0.071 | 0.12 | −0.039 | 0.77 | |
CD38 | 0.049 | 0.2720 | 0.064 | 0.1560 | −0.0043 | 0.92 | 0.14 | 0.29 | |
CD8+ T cell | CD8A | 0.201 | *** | 0.231 | *** | 0.078 | 0.085 | 0.11 | 0.41 |
CD8B | 0.192 | *** | 0.202 | *** | 0.12 | 0.0082** | 0.085 | 0.52 | |
BCL6 | 0.019 | 0.6600 | 0.024 | 0.5960 | 0.056 | 0.22 | 0.13 | 0.31 | |
ICOS | 0.162 | 0.0002*** | 0.202 | *** | 0.069 | 0.13 | 0.32 | 0.014** | |
CXCR5 | −0.013 | 0.7760 | −0.005 | 0.9150 | −0.098 | 0.032 | 0.4 | 0.0017** | |
Th1 | T-bet (TBX21) | 0.156 | 0.0004*** | 0.184 | *** | 0.035 | 0.44 | −0.033 | 0.8 |
STAT4 | 0.081 | 0.0646 | 0.098 | 0.0291 | 0.033 | 0.47 | 0.31 | 0.18 | |
IL12RB2 | 0.457 | *** | 0.483 | *** | 0.22 | *** | 0.14 | 0.29 | |
WSX1(IL27RA) | −0.047 | 0.2900 | −0.043 | 0.3410 | −0.058 | 0.21 | 0.24 | 0.071 | |
STAT1 | 0.44 | *** | 0.472 | *** | 0.3 | *** | 0.12 | 0.36 | |
IFN-γ(IFNG) | 0.311 | *** | 0.337 | *** | 0.19 | 0.000026*** | 0.075 | 0.57 | |
TNF-α(TNF) | 0.103 | 0.0194* | 0.124 | 0.0056** | 0.055 | 0.23 | 0.33 | 0.011* | |
Th2 | GATA3 | 0.174 | 0.0001*** | 0.204 | *** | 0.19 | 0.000026*** | 0.03 | 0.82 |
CCR3 | −0.02 | 0.6430 | 0.001 | 0.9890 | −0.015 | 0.74 | 0.11 | 0.41 | |
STAT6 | −0.07 | 0.1120 | −0.077 | 0.0858 | −0.028 | 0.55 | 0.27 | 0.042* | |
STAT5A | 0.055 | 0.2140 | 0.076 | 0.0925 | −0.0088 | 0.85 | 0.44 | 0.00056** | |
Th9 | TGFBR2 | −0.13 | 0.0032** | −0.123 | 0.0064*** | −0.12 | 0.0077*** | −0.19 | 0.14 |
IRF4 | 0.062 | 0.1620 | 0.077 | 0.0858 | −0.068 | 0.13 | 0.44 | 0.00053** | |
PU.1(SPI1) | −0.039 | 0.3770 | −0.038 | 0.4040 | −0.11 | 0.015* | 0.24 | 0.071 | |
Th17 | STAT3 | 0.023 | 0.5980 | 0.021 | 0.6350 | 0.021 | 0.64 | 0.12 | 0.38 |
IL-21R | 0.149 | 0.0007*** | 0.188 | *** | 0.037 | 0.41 | 0.26 | 0.05 | |
IL-23R | 0.002 | 0.9580 | 0.006 | 0.9010 | −0.033 | 0.47 | 0.11 | 0.39 | |
IL-17A | 0.089 | 0.0436* | 0.089 | 0.0494 | 0.073 | 0.11 | 0.17 | 0.19 | |
Th22 | CCR10 | 0.094 | 0.0321* | 0.08 | 0.0774 | 0.11 | 0.013* | −0.086 | 0.52 |
AHR | −0.014 | 0.7550 | −0.014 | 0.7500 | −0.012 | 0.79 | 0.003 | 0.98 | |
Treg | FOXP3 | 0.157 | 0.0004*** | 0.183 | *** | 0.04 | 0.38 | 0.42 | 0.001** |
CD25(IL2RA) | 0.24 | *** | 0.271 | *** | 0.15 | 0.00068 | 0.11 | 0.39 | |
CCR8 | 0.183 | *** | 0.214 | *** | 0.064 | 0.16 | 0.21 | 0.11 | |
T cell exhaustion | PD-1(PDCD1) | 0.219 | *** | 0.259 | *** | 0.083 | 0.068 | 0.38 | 0.0029** |
CTLA4 | 0.24 | *** | 0.29 | *** | 0.14 | 0.0029 | 0.27 | 0.04 | |
LAG3 | 0.265 | *** | 0.286 | *** | 0.12 | 0.0086 | 0.43 | 0.00071*** | |
TIM-3(HAVCR2) | 0.074 | 0.0951 | 0.088 | 0.0516 | −0.033 | 0.46 | 0.097 | 0.46 | |
Macrophage | CD68 | 0.034 | 0.4350 | 0.044 | 0.3340 | −0.032 | 0.49 | 0.15 | 0.26 |
CD11b (ITGAM) | 0.006 | 0.9000 | 0.019 | 0.6670 | −0.026 | 0.57 | 0.23 | 0.074 | |
M1 | INOS(NOS2) | 0.042 | 0.3420 | 0.029 | 0.5260 | 0.048 | 0.29 | −0.25 | 0.058 |
IRF5 | 0.125 | 0.0045** | 0.134 | 0.0028 | 0.087 | 0.057 | 0.4 | 0.0016** | |
COX2(PTGS2) | 0.016 | 0.7150 | 0 | 0.9920 | 0.02 | 0.66 | −0.048 | 0.72 | |
M2 | CD16 | 0.042 | 0.3440 | 0.055 | 0.2230 | −0.0086 | 0.85 | 0.065 | 0.62 |
ARG1 | −0.001 | 0.9830 | −0.011 | 0.8150 | 0.059 | 0.19 | −0.038 | 0.77 | |
MRC1 | −0.083 | 0.0588 | −0.079 | 0.0786 | −0.075 | 0.1 | 0.38 | 0.0031** | |
MS4A4A | −0.001 | 0.9860 | 0.007 | 0.8760 | −0.083 | 0.069 | 0.25 | 0.06 | |
TAM | CCL2 | 0.074 | 0.0921 | 0.081 | 0.0739 | 0.0014 | 0.97 | −0.015 | 0.91 |
CD80 | 0.129 | 0.0033** | 0.153 | 0.0006 | 0.079 | 0.082 | 0.15 | 0.25 | |
CD86 | 0.078 | 0.0755 | 0.095 | 0.0355 | −0.028 | 0.54 | 0.22 | 0.1 | |
CCR5 | 0.14 | 0.0014 | 0.177 | 0.0001 | 0.056 | 0.22 | 0.27 | 0.04* | |
Monocyte | CD14 | 0.041 | 0.3530 | 0.058 | 0.1960 | −0.06 | 0.19 | −0.12 | 0.35 |
CD16(FCGR3B) | 0.042 | 0.3440 | 0.055 | 0.2230 | −.0086 | 0.85 | 0.065 | 0.62 | |
CD115(CSF1R) | 0.011 | 0.8050 | 0.026 | 0.5690 | −0.047 | 0.3 | 0.34 | 0.00088** | |
Neutrophil | CD66b (CEACAM8) | −0.23 | *** | −0.229 | *** | −0.1 | 0.025 | −0.013 | 0.92 |
CD15(FUT4) | 0.058 | 0.1890 | 0.047 | 0.2940 | 0.15 | 0.0013 | 0.15 | 0.26 | |
CD11b (ITGAM) | 0.006 | 0.9000 | 0.019 | 0.6670 | −0.026 | 0.57 | 0.23 | 0.074 | |
Natural killer cell | XCL1 | 0.225 | *** | 0.261 | *** | 0.2 | 0.0000058 | −0.17 | 0.19 |
CD7 | 0.191 | *** | 0.219 | *** | 0.063 | 0.17 | 0.16 | 0.22 | |
KIR3DL1 | 0.035 | 0.4270 | 0.042 | 0.3560 | 0.00052 | 0.99 | −0.19 | 0.16 | |
Dendritic cell | CD1C(BDCA-1) | −0.339 | *** | −0.344 | *** | −0.23 | 0.00000028 | 0.11 | 0.43 |
CD141 (THBD) | −0.183 | *** | −0.188 | *** | −0.075 | 0.1 | −0.12 | 0.38 | |
CD11c | 0.133 | 0.0026** | 0.154 | 0.0006 | 0.011 | 0.81 | 0.35 | 0.0071** |
correlation without adjustment, Purity: correlation adjusted by purity, Cor, correlation coefficient. *p < 0.05, **p < 0.01, and ***p < 0.001.