Table 1B.

Top pathways associated with upregulated proteins (listed in Table 1A) altered with Aquamin.

Pathway name	Entities p-value	Mapped entities
HDL clearance	0.004	Apoa1
Scavenging by Class B Receptors	0.005	Apoa1
Utilization of Ketone Bodies	0.005	Oxct1
RHO GTPases Activate Rhotekin and Rhophilins	0.008	Tax1bp3
HDL assembly	0.009	Apoa1
Post-translational protein phosphorylation	0.010	Apoa1;Serpind1
Regulation of IGF transport and uptake by IGFBPs	0.011	Apoa1;Serpind1
HDL remodeling	0.012	Apoa1
Chylomicron remodeling	0.013	Apoa1
Chylomicron assembly	0.013	Apoa1
Scavenging by Class A Receptors	0.013	Apoa1
Ketone body metabolism	0.013	Oxct1
Dermatan sulfate biosynthesis	0.014	Bgn
Heme signaling	0.014	Apoa1
CS/DS degradation	0.018	Bgn
Metabolism of Angiotensinogen to Angiotensins	0.021	Agt
ABC transporters in lipid homeostasis	0.022	Apoa1
Plasma lipoprotein assembly	0.024	Apoa1
Chondroitin sulfate biosynthesis	0.026	Bgn
Common Pathway of Fibrin Clot Formation	0.027	Serpind1
Intrinsic Pathway of Fibrin Clot Formation	0.030	Serpind1
A tetrasaccharide linker sequence is required for GAG synthesis	0.034	Bgn
Plasma lipoprotein remodeling	0.035	Apoa1
Plasma lipoprotein clearance	0.039	Apoa1

The pathways listed here are altered by the significantly upregulated proteins with the intervention “Aquamin” presented in Table 1A. Reactome (v78) was used to generate the pathway analysis report for species Mus musculus. The significance (p-value) is calculated by the overrepresentation analysis (hypergeometric distribution). IGF, Insulin-like Growth Factor; IGFBPs, Insulin-like growth factor binding proteins.