Table 2.
Comparison of 3-HP production with glucose as the sole carbon source in Escherichia coli.
| Production host | Strategies | Productivity (g/L/h) | Yield (g/g) | Titer (g/L) | Reactor | References |
|---|---|---|---|---|---|---|
| Q-3434 | Regulating DtsR1, AccBC expression level and balancing strength of Acc and MCR | 0.13 1.03 |
0.566 0.246 |
6.8 38.13 |
Shake flask 7.5 L bioreactor |
This study |
| BE-MDA | Heterologous expressing acetyl-CoA carboxylase from C. glutamicum | 0.04 0.40 |
0.18 – |
1.80 10.08 |
Shake flask 5 L bioreactor |
Cheng et al., 2016 |
| Q2186 | Balancing activity level of MCR-C and MCR-N | 0.08 0.56 |
– 0.19 |
3.72 40.60 |
Shake flask 5 L bioreactor |
Liu et al., 2016 |
| Ec-MAP | Enhancing mal-CoA and NADPH supply | 8.03E-3 | – | 0.19 | Shake flask | Rathnasingh et al., 2012 |
| pMCR-N-C | Increasing malonyl-CoA reductase activity by dissection | 3.13E-3 | – | 0.15 | Shake flask | Liu et al., 2013 |
| CWF4NAS containing pTac15kPTA and p100-99A-DT12P | Introducing heterologous genes, pyruvate transaminase (encoded by pa0132), and overexpressing malonic acid reductase (encoded by ydf G), semialdehyde dehydrogenase (encoded by yneI) in β-alanine pathway | 0.63 | 0.423 | 31.1 | 6.6 L bioreactor | Qin et al., 2020 |