TABLE 4.
Comparison between free drugs and NPs against B. melitensis inside J774A.1 cells.
| Treatment | Concentration (µg/ml) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 100 | 50 | 25 | 12.5 | 6.25 | ||||||
| Mean CFUs ±SEM | Log CFUs reduction | Mean CFUs ±SEM | Log CFUs reduction | Mean CFUs ±SEM | Log CFUs reduction | Mean CFUs ±SEM | Log CFUs reduction | Mean CFUs ±SEM | Log CFUs reduction | |
| Free SLN | 6.5 ± 0.07 | 0 | 6.5 ± 0.07 | 0 | 6.5 ± 0.07 | 0 | 6.5 ± 0.07 | 0 | 6.5 ± 0.07 | 0 |
| Free Doxycycline | 5.5 ± 0.03 | 1 | 5.7 ± 0.02 | 0.8 | 5.8 ± 0.01 | 0.7 | 6.0 ± 0.03 | 0.5 | 6.1 ± 0.04 | 0.4 |
| Free Hydroxychloroquine | 6.4 ± 0.01 | 0.1 | 6.4 ± 0.03 | 0.1 | 6.4 ± 0.09 | 0.1 | 6.4 ± 0.01 | 0.1 | 6.4 ± 0.06 | 0.1 |
| DOX-SLN | 4.2 ± 0.04 | 2.3 | 4.5 ± 0.05 | 2.0 | 4.9 ± 0.01 | 1.6 | 5.1 ± 0.07 | 1.4 | 5.2 ± 0.04 | 1.3 |
| HYD-SLN | 6.4 ± 0.01 | 0.1 | 6.4 ± 0.05 | 0.1 | 6.4 ± 0.03 | 0.1 | 6.4 ± 0.06 | 0.1 | 6.4 ± 0.05 | 0.1 |
| DOX-HYD-SLN | 3.5 ± 0.07 | 3 | 3.7 ± 0.02 | 2.8 | 3.8 ± 0.05 | 2.7 | 4.1 ± 0.07 | 2.4 | 4.9 ± 0.09 | 1.6 |
| Negative control | 6.5 ± 0.05 | 0 | 6.5 ± 0.05 | 0 | 6.5 ± 0.05 | 0 | 6.5 ± 0.05 | 0 | 6.5 ± 0.05 | 0 |