Skip to main content
. 2022 Feb 12;9(15):2003699. doi: 10.1002/advs.202003699

Figure 4.

Figure 4

Preparation and application of boronic acid‐rich dendrimer (BARD)‐mediated intracellular superoxide dismutase (SOD) delivery. a–c) Intravitreal injection of BARD/SOD nanoformulations for intracellular SOD delivery. a) The eyeball structure from outside to inside were enlarged, and presented from right to left. b) Binding curve and c) fractional saturation curve of BARD/SOD‐FITC nanoformulations at different polymer concentrations, and SOD‐FITC was fixed at 176 nm. n = 3, data presented as mean ± SD. d–h) Confocal microscope images of Brn3a (green), TUNEL (red), Hoechst (blue), and merged staining in the ganglion cell layer (GCL). d) Normal control rat; e) normal rat injected with SOD; f) normal rat injected with BARD/SOD nanoformulation; g) normal rat injected with BARD; h) ischemia/reperfusion rat. Scale bar: 20 µm. RGC, retinal ganglion cell; BC, bipolar cell; HC, horizontal cell; AC, amacrine cell. ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer. Reproduced with permission.[ 33 ] Copyright 2020, Elsevier Ltd.