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. 2022 Feb 12;9(15):2003699. doi: 10.1002/advs.202003699

Figure 6.

Figure 6

Chitosan (CHI)‐based self‐assembly nanofilms for corneal wound repair. a) Schematic illustration of conventional layer‐by‐layer (LbL) and shear flow‐driven LbL (SF‐LbL) assembly processes. Polymer molecules mainly showed a random coil structure in static solution, but achieved a more stretched structure in flow state via coil‐stretch transition. b–d) Remodeling of acellular matrix of the porcine cornea and modification of a rat eye in situ by SF‐LbL‐assembled coating strategy. b) Schematic illustration of (CHI‐FITC/hyaluronic acid (HA))15 film fabrication on a wounded porcine eye in situ. c) Bright‐field (top) and fluorescence (bottom) photos of an alkali‐burned rat eye covered with SF‐LbL‐assembled (CHI‐FITC/HA)15 films. d) Fluorescence images of a repaired rat cornea in histologic section. Scale bars = 200 µm. Reproduced with permission.[ 45 ] Copyright 2019, American Chemical Society.