TABLE 2B.

Comparison of Z-score between baseline and after unilateral deep brain stimulation of the globus pallidus internus (GPi-DBS) by brain perfusion single photon emission computed tomography (SPECT).

Location*	Change in pre- and post-op CBF	Z-score		p	Normalization in post-op CBF
		Pre-op	Post-op
<Good responders>
Ipsilateral transverse temporal	↓	–0.271	0.185	0.02	Yes
Contralateral premotor	↑	0.303	–0.001	0.02	Yes
Contralateral medial frontal	↑	–0.258	–0.482	0.02	Not
Contralateral inferior frontal	↑	–0.236	–0.569	0.03	Not
Contralateral Broca*	↑	–0.100	–0.443	0.03	Not
Contralateral Wernicke*	↑	0.676	0.301	0.03	Yes
Contralateral orbital	↑	–0.597	–0.908	0.04	Not
Contralateral middle frontal	↑	–0.091	–0.400	0.04	Not
Ipsilateral globus pallidus	↓	–0.476	0.318	0.04	Yes
Ipsilateral cingulate	↓	0.279	0.499	0.04	Not
Contralateral primary auditory**	↑	0.138	–0.021	0.04	Yes
Contralateral middle temporal	↑	0.104	–0.249	0.045	Not
<Poor responders>
Ipsilateral parahippocampal	↓	–0.370	0.747	0.002	Not
Contralateral caudate head	↓	0.677	0.887	0.002	Not
Ipsilateral nucleus ruber	↓	–0.151	0.532	0.01	Not
Ipsilateral inferior temporal	↑	–0.079	–0.342	0.02	Not
Ipsilateral globus pallidus	↓	–0.243	0.261	0.02	Not
Contralateral fusiform	↓	–0.016	0.164	0.04	Not
Ipsilateral anterior cingulate	↓	–0.128	0.331	0.047	Not

Patients were divided into good and poor responders based on changes in Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) part III ipsilateral sub scores after surgery. *These locations overlap anatomically with frontal and temporal lobes. **Primary auditory overlaps anatomically with frontal lobes. ↑: increased CBF, ↓: decreased CBF.