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. 2022 May 25;13(5):500. doi: 10.1038/s41419-022-04964-w

Fig. 4. C5aR1 inhibition restores neuronal plasticity in paclitaxel-treated F11 cells.

Fig. 4

Quantification of the expression of phosphorylated and total forms of p-cortactin (A), p-FAK (B), p-JAK2 (C) and p-STAT3 (D) in differentiated F11 cells following paclitaxel (PAC) or C5a treatment evaluated by western blot analysis. Expression of p-cortactin and p-FAK (E), p-JAK2 and p-STAT3 (F), and TRPV1 and TRPV4 (G) in differentiated F11 cells exposed to paclitaxel and treated or not with a C5aR1 inhibitor, DF3966A. F11 cells were treated for 24 h with PAC (10 nM), C5a (50 nM) or DF3966A (10 µM) or PAC (10 nM) + DF3966A (10 µM). ***P < 0.0005; **P < 0.005; *P < 0.05 vs CTR; +++P < 0.0005; ++P < 0.005; +P < 0.05 vs paclitaxel. Data are mean ± SEM of n = 3 different experiments.