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. 2022 May 25;13(5):500. doi: 10.1038/s41419-022-04964-w

Fig. 5. C5aR1 inhibition counteracts paclitaxel-induced alterations in rodent DRG.

Fig. 5

Representative trace of electrophysiological recordings in DRG cells maintained under basal conditions (A), and in cells challenged with paclitaxel (10 nM) (PAC) (B), paclitaxel+DF3966A (1 µM) (C), C5a (100 nM) (D) or C5a + DF3966A (E). Quantitative evaluation of action potential firing rate in DRG exposed to paclitaxel alone or in combination with DF3966A (F), and C5a alone or in combination with DF3966A (G). DRG-derived neurons were cultured for 7 days. Cells were treated for 1 min 30 s (short) or 5 min (long). **P < 0.005 and *P < 0.05 vs respective basal condition; +P < 0.05 vs paclitaxel or C5a. Data are mean ± SEM of n = 3 different experiments.