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The effect of AGEs on the epidermis of the skin. (A) AGEs obstruct skin wound healing. (B) AGEs reduce the contents of ceramide (CER) and cholesterol (CHOL) in the epidermis, eventually leading to a reduction in skin lipid content. (C) AGEs destroy the keratinocyte cell structure in the epidermis. (D) AGEs promote the production of melanin in melanocytes.
