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The effect of AGEs on the dermis of the skin. AGEs and collagen are cross-linked, causing the protein to brown and the fibers to deform. Elastin fiber becomes thinner, less rigid, and loses its biological properties. Glycosylated vimentin leads to the loss of fibroblasts’ contraction ability and the inability to maintain the basic cell shape. AGEs bind to RAGE receptors to regulate gene expression and mediate a series of signal pathways.
