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The mechanisms of AGEs inhibition. (A) Maintain and stabilize the protein structure. (B) Chelation of transition metals. (C) Capture and block dicarbonyl compounds. (D) Neutralize, inhibit, and scavenge oxidative free radicals. (E) Activation of the glyoxalase detoxification system. (F) Inhibition of aldose reductase. (G) Activation of the proteolytic system. (H) Regulation of AGE-RAGE signal transduction. (I) Disruption of protein cross-linking.
