TABLE 2.
Parkinson’s disease clinical characteristics.
Age at diagnosis, (years) [SD, range]* | 58.8 [13.6, 24–88] |
Parkinson’s disease duration, (years) [SD, range]* | 9.2 [6.5, 1–30] |
Parkinson’s disease phenotype, (%)* | |
Tremor Dominant | 30.1 |
Postural Instability and gait Impairment | 20.4 |
Akinetic rigid | 38.9 |
Young onset (<40years) | 10.7 |
Late onset (>60years) | 49.5 |
Genetic diagnosis, (%)* | 1.9 |
Disease complications, (%)* | |
Motor fluctuations | 58.3 |
Dyskinesia | 58.3 |
Wearing off | 81.6 |
Impulse control disorder | 19.4 |
Non-motor symptoms, (%)* | |
Hyposmia | 73.8 |
REM sleep behavior disorder | 48.5 |
Constipation | 60.2 |
Levodopa equivalent daily dose (mg), [SD, range]* | 834.8 [527.3, 0–2,186] |
MDS unified Parkinson’s disease rating scale-III (“on” state), [SD, range]* | 32.9 [17.7, 5–91] |
Quality of life | |
PDQ-39 summary index, [SD] | 29.2 [17.3] |
MDS Non-motor symptoms score (NMSS)—total score, [SD]* | 62.7 [42.9] |
Parkinson’s disease therapy, (%)* | |
Treatment naïve | (n = 5) 4.9 |
Oral levodopa | (n = 92) 89.3 |
Dopamine agonist | (n = 36) 35.0 |
Monoamine oxidase B inhibitor | (n = 19) 18.4 |
Anticholinergic | (n = 13) 12.6 |
Catechol-O-methyl transferase inhibitor | (n = 24) 23.3 |
Amantadine | (n = 13) 12.6 |
Levodopa-carbidopa intestinal gel (LCIG) | (n = 9) 8.7 |
Deep brain stimulation | (n = 11) 10.7 |
Apomorphine (subcutaneous infusion) | (n = 7) 6.8 |
SD, (Standard Deviation). *This data is partially reproduced (Lubomski et al., 2020b).