Figure 2.

Genetic correlations between asthma-COPD overlap (ACO) and asthma, moderate-severe asthma, COPD, FEV₁/FVC, and blood eosinophil counts. Genetic correlations were computed by linkage disequilibrium score regression. The annotation in each tile represents the magnitude of the genetic correlation estimate (rG), and intensity is proportional to the magnitude of effect. Note that for FEV₁/FVC, a negative correlation shows that the other trait is associated with reduced FEV₁/FVC (reduced FEV₁/FVC implies worse lung function). Data sets used: ACO = current discovery results from UK Biobank; Asthma = GWAS results from Demenais et al²⁹; Asthma (moderate-severe) = genome-wide association study (GWAS) of asthma by Shrine et al³⁰; COPD = GWAS of COPD by Sakornsakolpat et al³¹; FEV₁/FVC = GWAS of FEV₁/FVC (UK Biobank and SpiroMeta) by Shrine et al³³; Eosinophils = blood eosinophil counts published by Astle et al.³²