TABLE 4.
Rel. WMH1 |
Abs. WMH1,2 |
FA3 |
||||
Men (N = 264) |
Women (N = 315) |
Men (N = 264) |
Women (N = 315) |
Men (N = 262) |
Women (N = 316) |
|
|
|
|
|
|
|
|
(p-value) | (p-value) | (p-value) | (p-value) | (p-value) | (p-value) | |
Constant | −3.658*** (1.77e-12) | −4.622*** (<2e-16) | −4.335*** (8.0e-06) | −4.730*** (3.15e-07) | 0.400*** (<2e-16) | 0.405*** (<2e-16) |
Age (in years) | 0.050*** (4.90e-08) | 0.053*** (4.71e-09) | 0.048*** (1.2e-07) | 0.051*** (2.52e-08) | −0.001*** (7.7e-09) | −0.001*** (2.4e-08) |
Smoking (Ref: Never) | ||||||
Former | −0.216 (0.163) | 0.156 (0.266) | −0.227 (0.143) | 0.135 (0.343) | −0.002 (0.543) | −0.002 (0.312) |
Current | −0.306 (0.104) | 0.513** (0.004) | −0.350 (0.062) | 0.530** (0.003) | −0.006 (0.058) | −0.003 (0.211) |
Diabetes (Ref: No) | ||||||
Yes | −0.041 (0.909) | 0.273 (0.437) | −0.004 (0.992) | 0.286 (0.420) | −0.001 (0.904) | −0.007 (0.147) |
Hypertension (Ref: untreated, controlled) | ||||||
Untreated, uncontrolled | −0.146 (0.359) | −0.048 (0.770) | −0.150 (0.344) | −0.054 (0.744) | −0.001 (0.583) | −0.005* (0.035) |
Treated, controlled | 0.145 (0.591) | 0.538* (0.024) | 0.179 (0.501) | 0.568* (0.019) | −0.003 (0.463) | −0.009* (0.015) |
Treated, uncontrolled | 0.162 (0.445) | 0.576** (0.007) | 0.191 (0.363) | 0.580** (0.007) | −0.004 (0.206) | −0.011*** (4.03e-4) |
Obesity (Ref: No) | ||||||
Yes | 0.151 (0.394) | 0.182 (0.258) | 0.143 (0.416) | 0.173 (0.289) | 0.002 (0.516) | −0.001 (0.766) |
Results from sex-stratified analysis.
*p < 0.05, **p < 0.01, ***p < 0.001.
1Results from generalized linear models with Gamma distribution and log-link function, additionally adjusted for education.
2Additionally adjusted for intracranial volume.
3Results from ordinary least squares (OLS) regression analysis, additionally adjusted for education.