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. 2022 May 6;10(13):3989–4019. doi: 10.12998/wjcc.v10.i13.3989

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Solute carrier family 2 member 1 expression was increased whereas solute carrier family 2 member 2 expression was decreased in liver cancer. A: The reads per kilobase million (RPKM) of solute carrier family 2 in normal liver tissues from 95 human individuals by National Center for Biotechnology Information's gene database. The RPKM of solute carrier family 2 member 2 (SLC2A2) was 193.619, while solute carrier family 2 member 1 (SLC2A1) was almost undetectable; B: The fragments per kilobase million (FPKM) of solute carrier family 2 in HepG2 cells by RNA sequencing. The FPKM of SLC2A1 was 314.336 while SLC2A2 was 2.68857 in HepG2 cells; C: The FPKM of solute carrier family 2 in HepG2215 cells by RNA sequencing. The FPKM of SLC2A1 was 412.048 while SLC2A2 was 12.0905 in HepG2215 cells; D: The messenger RNA expression level of SLC2A1 was increased while that of SLC2A2 was decreased in hepatocellular carcinoma (HCC) in the cohort [gene expression series 121248 (GSE121248)]; E: The messenger RNA expression level of SLC2A1 was increased while that of SLC2A2 was decreased in HCC compared with normal tissues in The Cancer Genome Atlas (TCGA); F: Immunofluorescence analysis revealed that SLC2A1 protein expression was expressed and SLC2A2 protein expression was weakly expressed in HepG2 cells in the Human Protein Atlas; G: Immunohistochemical analysis showed the expression level of SLC2A1 was increased while SLC2A2 was decreased in liver cancer compared with normal tissues in the Human Protein Atlas. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001.