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. 2022 May 6;10(13):3989–4019. doi: 10.12998/wjcc.v10.i13.3989

Figure 8.

Figure 8

Solute carrier family 2 member 1 and solute carrier family 2 member 2 expressions correlated with immune marker genes in hepatocellular carcinoma by using tumor immune estimation resource and gene expression profiling interactive analysis databases. A: Solute carrier family 2 member 1 (SLC2A1) expression correlated with macrophage polarization in hepatocellular carcinoma (HCC). Markers included CD86 and CD115 of monocytes; C-C motif chemokine ligand 2, CD68, and interleukin (IL) 10 of tumor-associated macrophage; nitric oxide synthase 2, interferon regulatory factor 5, and COX2 cytochrome c oxidase subunit II of M1 macrophages; and CD163, V-set and immunoglobulin domain containing 4, and membrane spanning 4-domains A4A of M2 macrophages; B: Solute carrier family 2 member 2 (SLC2A2) expression correlated with macrophage polarization in HCC. Markers included CD86 and CD115 of monocytes; C-C motif chemokine ligand 2, CD68, and IL10 of tumor-associated macrophage; nitric oxide synthase 2, interferon regulatory factor 5, and COX2 cytochrome c oxidase subunit II of M1 macrophages; and CD163, V-set and immunoglobulin domain containing 4, and membrane spanning 4-domains A4A of M2 macrophages; C: SLC2A1 expression was correlated with functional T cells in HCC. Markers included BCL6 transcription repressor and IL21 of follicular helper T; C-C motif chemokine receptor 8, signal transducer and activator of transcription (STAT) 5B, and transforming growth factor-beta markers of T cell regulatory; STAT1, interferon gamma, and tumor necrosis factor of T helper (Th)1; and GATA binding protein 3, STAT6, and STAT5A of Th2; D: SLC2A2 expression was correlated with functional T cells in HCC. Markers included BCL6 transcription repressor and IL21 of follicular helper T; C-C motif chemokine receptor 8,, STAT5B, and transforming growth factor-beta markers of T cell regulatory; STAT1, interferon gamma, and tumor necrosis factor alpha of Th1 and GATA binding protein 3, STAT6 and STAT5A of Th2; E: SLC2A1 expression correlated with T cell exhaustion in HCC. Markers included programmed cell death 1, cytotoxic T-lymphocyte associated protein 4, lymphocyte activating 3, hepatitis A virus cellular receptor 2, and granzyme B; F: SLC2A2 expression correlated with T cell exhaustion in HCC. Markers included programmed cell death 1, cytotoxic T-lymphocyte associated protein 4, lymphocyte activating 3, hepatitis A virus cellular receptor 2, and granzyme B. TAM: Tumor-associated macrophage; CCL2: C-C motif chemokine ligand 2; IL10: interleukin 10; NOS2: nitric oxide synthase 2; IRF5: interferon regulatory factor 5; PTGS2: COX2 cytochrome c oxidase subunit II;VSIG4: V-set and immunoglobulin domain containing 4; MS4A4A: membrane spanning 4-domains A4A; Tfh: Follicular helper T; BCL6: BCL6 transcription repressor; IL21: Interleukin 21; Treg: T cell regulatory; CCR8: C-C motif chemokine receptor 8; STAT5B: signal transducer and activator of transcription 5B; TGFB1: transforming growth factor-beta; Th: T helper; STAT1: signal transducer and activator of transcription 1; IFNG: interferon gamma; TNF: tumor necrosis factor; GATA3: GATA binding protein 3; STAT6: signal transducer and activator of transcription 6; STAT5A: signal transducer and activator of transcription 5A; PDCD1: programmed cell death 1; CTLA4: cytotoxic T-lymphocyte associated protein 4; LAG3: lymphocyte activating 3; HAVCR2: hepatitis A virus cellular receptor 2; GZMB: granzyme B.