Table 3.
Correlation analysis between solute carrier family 2 member 1 and solute carrier family 2 and genes markers of immune cells in tumor immune estimation resource
| Description | Gene markers |
Solute carrier family 2 member 1
|
Solute carrier family 2 member 2
|
||||||
|
None
|
Purity
|
None
|
Purity
|
||||||
|
cor
|
P
value
|
cor
|
P
value
|
cor
|
P
value
|
cor
|
P
value
|
||
| CD8+ T cell | |||||||||
| CD8A | 0.216 | 2.88E-05 | 0.173 | 1.27E-03 | -0.103 | 4.85E-02 | -0.027 | 6.15E-01 | |
| CD8B | 0.229 | 8.60E-06 | 0.195 | 2.72E-04 | -0.199 | 1.14E-04 | -0.138 | 1.04E-02 | |
| T cell (general) | |||||||||
| CD3D | 0.241 | 2.75E-06 | 0.22 | 3.73E-05 | -0.327 | 1.33E-10 | -0.276 | 1.88E-07 | |
| CD3E | 0.201 | 1.01E-04 | 0.162 | 2.59E-03 | -0.165 | 1.44E-03 | -0.087 | 1.08E-01 | |
| CD2 | 0.178 | 5.64E-04 | 0.138 | 1.04E-02 | -0.194 | 1.75E-04 | -0.121 | 2.48E-02 | |
| B cell | |||||||||
| CD19 | 0.208 | 5.50E-05 | 0.176 | 1.04E-03 | -0.137 | 8.06E-03 | -0.089 | 9.95E-02 | |
| CD79A | 0.099 | 5.72E-02 | 0.045 | 4.01E-01 | -0.138 | 7.84-03 | -0.07 | 1.92E-01 | |
| Monocyte | |||||||||
| CD86 | 0.413 | 0.00E+00 | 0.415 | 8.08E-16 | -0.196 | 1.50E-04 | -0.15 | 5.21E-03 | |
| CD115 (CSF1R) | 0.41 | 0.00E+00 | 0.408 | 3.06E-15 | -0.175 | 7.02E-04 | -0.126 | 1.96E-02 | |
| Tumor-associated macrophage | |||||||||
| CCL2 | 0.206 | 6.86E-05 | 0.162 | 2.53E-03 | -0.117 | 2.47E-02 | -0.042 | 4.32E-01 | |
| CD68 | 0.38 | 4.24E-14 | 0.381 | 2.40E-13 | -0.235 | 5.28E-06 | -0.192 | 3.26E-04 | |
| IL10 | 0.326 | 1.26E-10 | 0.309 | 4.43E-09 | -0.131 | 1.15E-02 | -0.078 | 1.48E-01 | |
| M1 macrophage | |||||||||
| INOS (NOS2) | 0.068 | 1.91E-01 | 0.052 | 3.39E-01 | 0.175 | 7.12E-04 | 0.18 | 7.95E-04 | |
| IRF5 | 0.142 | 6.33E-03 | 0.138 | 1.05E-02 | 0.011 | 8.39E-01 | 0.003 | 9.63E-01 | |
| COX2 (PTGS2) | 0.32 | 2.91E-10 | 0.313 | 2.80E-09 | -0.06 | 2.45E-01 | -0.007 | 9.03E-01 | |
| M2 macrophage | |||||||||
| CD163 | 0.28 | 3.94E-08 | 0.253 | 1.91E-06 | 0.046 | 3.72E-01 | 0.125 | 2.00E-02 | |
| VSIG4 | 0.353 | 3.65E-12 | 0.336 | 1.56E-10 | -0.06 | 2.46E-01 | -0.007 | 8.96E-01 | |
| MS4A4A | 0.337 | 3.49E-11 | 0.33 | 3.15E-10 | -0.057 | 2.69E-01 | 0.01 | 9.85E-01 | |
| CD66b (CEACAM8) | 0.086 | 9.68E-02 | 0.084 | 1.20E-01 | -0.036 | 4.89E-01 | -0.027 | 6.12E-01 | |
| CD11b (ITGAM) | 0.428 | 0.00E+00 | 0.405 | 4.71E-15 | -0.18 | 5.06E-04 | -0.156 | 3.75E-03 | |
| CCR7 | 0.088 | 8.89E-02 | 0.016 | 7.70E-01 | -0.032 | 5.35E-01 | -0.045 | 4.00E-01 | |
| KIR2DL1 | 0.083 | 1.09E-01 | 0.063 | 2.46E-01 | -0.003 | 9.51E-01 | 0.019 | 7.23E-01 | |
| KIR2DL3 | 0.179 | 5.16E-04 | 0.167 | 1.82E-03 | -0.006 | 9.15E-01 | -0.038 | 4.79E-01 | |
| KIR2DL4 | 0.234 | 5.38E-06 | 0.212 | 7.12E-05 | -0.133 | 1.06E-02 | -0.107 | 4.78E-02 | |
| KIR3DL1 | 0.146 | 4.97E-03 | 0.12 | 2.64E-02 | 0.079 | 1.30E-01 | 0.116 | 3.15E-02 | |
| KIR3DL2 | 0.098 | 6.04E-02 | 0.08 | 1.38E-01 | -0.027 | 6.02E-01 | 0.003 | 9.60E-01 | |
| KIR3DL3 | 0.06 | 2.53E-01 | 0.046 | 3.91E-01 | -0.021 | 6.91E-01 | -0.015 | 7.87E-01 | |
| KIR2DS4 | 0.117 | 2.39E-02 | 0.13 | 1.57E-02 | 0.04 | 4.37E-01 | 0.052 | 3.37E-01 | |
| HLA-DPB1 | 0.319 | 4.21E-10 | 0.296 | 2.07E-08 | -0.191 | 2.25E-04 | -0.138 | 1.03E-02 | |
| HLA-DQB1 | 0.221 | 1.77E-05 | 0.192 | 3.35E-04 | -0.219 | 2.09E-05 | -0.171 | 1.43E-03 | |
| HLA-DRA | 0.35 | 5.25E-12 | 0.326 | 5.24E-10 | -0.117 | 2.37E-02 | -0.055 | 3.09E-01 | |
| HLA-DPA1 | 0.338 | 3.01E-11 | 0.316 | 1.92E-09 | -0.114 | 2.88E-02 | -0.052 | 3.34E-01 | |
| BDCA-1 (CD1C) | 0.061 | 2.45E-01 | 0.024 | 6.52E-01 | 0.004 | 9.40E-01 | 0.073 | 1.77E-01 | |
| BDCA-4 (NRP1) | 0.357 | 1.99E-12 | 0.352 | 1.70E-11 | 0.043 | 4.13E-01 | 0.087 | 1.08E-01 | |
| CD11c (ITGAX) | 0.382 | 2.93E-14 | 0.38 | 2.50E-13 | -0.154 | 2.93E-03 | -0.118 | 2.86E-02 | |
| Th1 | |||||||||
| T-bet (TBX21) | 0.095 | 6.88E-02 | 0.042 | 4.32E-01 | 0.025 | 6.38E-01 | 0.116 | 3.07E-02 | |
| STAT4 | 0.082 | 1.13E-01 | 0.045 | 4.04E-01 | -0.106 | 4.22E-02 | -0.058 | 2.84E-01 | |
| STAT1 | 0.314 | 7.29E-10 | 0.29 | 4.18E-08 | 0.023 | 6.52E-01 | 0.058 | 2.84E-01 | |
| IFN-γ (IFNG) | 0.237 | 3.81E-06 | 0.212 | 7.39E-05 | -0.169 | 1.09E-03 | -0.122 | 2.31E-02 | |
| TNF-α (TNF) | 0.277 | 6.15E-08 | 0.257 | 1.34E-06 | -0.147 | 4.67E-03 | -0.092 | 8.91E-02 | |
| Th2 | |||||||||
| GATA3 | 0.248 | 1.34E-06 | 0.235 | 1.03E-05 | -0.176 | 6.76E-04 | -0.108 | 4.52E-02 | |
| STAT6 | 0.27 | 1.35E-07 | 0.255 | 1.63E-06 | 0.178 | 5.68E-04 | 0.19 | 3.82E-04 | |
| STAT5A | 0.37 | 1.83E-13 | 0.338 | 1.18E-10 | -0.097 | 6.27E-02 | -0.055 | 3.12E-01 | |
| IL13 | -0.081 | 1.19E-01 | -0.113 | 3.56E-02 | 0.077 | 1.38E-01 | 0.09 | 9.40E-02 | |
| Tfh | |||||||||
| BCL6 | 0.267 | 2.04E-07 | 0.281 | 1.16E-07 | 0.227 | 1.08E-05 | 0.228 | 1.94E-05 | |
| IL21 | 0.124 | 1.65E-02 | 0.13 | 1.55E-02 | -0.065 | 2.15E-01 | -0.06 | 2.68E-01 | |
| Th17 | |||||||||
| IL17A | -0.047 | 3.68E-01 | -0.033 | 5.46E-01 | 0.04 | 4.47E-01 | -0.051 | 3.41E-01 | |
| T cell regulatory | |||||||||
| FOXP3 | 0.068 | 1.89E-01 | -0.039 | 4.68E-01 | 0.169 | 1.07E-03 | 0.189 | 4.24E-04 | |
| CCR8 | 0.286 | 1.95E-08 | 0.264 | 6.44E-07 | -0.056 | 2.79E-01 | -0.008 | 8.86E-01 | |
| STAT5B | 0.156 | 2.63E-03 | 0.173 | 1.29E-03 | 0.402 | 0.00E+00 | 0.397 | 1.83E-14 | |
| TGFβ (TGFB1) | 0.314 | 7.92E-10 | 0.303 | 8.83E-09 | -0.281 | 4.30E-08 | -0.242 | 5.53E-06 | |
| T cell exhaustion | |||||||||
| PD-1 (PDCD1) | 0.256 | 5.91E-07 | 0.232 | 1.31E-05 | -0.281 | 3.50E-08 | -0.238 | 7.71E-06 | |
| CTLA4 | 0.284 | 2.57E-08 | 0.266 | 5.31E-07 | -0.327 | 1.15E-10 | -0.283 | 8.93E-08 | |
| LAG3 | 0.156 | 2.67E-02 | 0.127 | 1.83E-02 | -0.195 | 1.66E-04 | -0.165 | 2.15E-03 | |
| TIM-3 (HAVCR2) | 0.434 | 0.00E+00 | 0.437 | 1.52E-17 | -0.255 | 6.91E-07 | -0.228 | 1.89E-05 | |
| GZMB | 0.176 | 6.91E-04 | 0.131 | 1.51E-02 | -0.124 | 1.70E-02 | -0.068 | 2.10E-01 | |
cor: Correlation coefficient; L10: Interleukin 10; INOS: Nitric oxide synthase 2; IRF5: Interferon regulatory factor 5; COX2: Cytochrome c oxidase subunit II; VSIG4: V-set and immunoglobulin domain containing 4; MS4A4A: Membrane spanning 4-domains A4A; CCR7: C-C motif chemokine receptor 7; KIR2DL1: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1; KIR2DL3: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3; KIR2DL4: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4; KIR3DL1: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1; KIR3DL2: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2; KIR3DL3: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3; KIR2DS4: Killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4; HLA-DPB1: Major histocompatibility complex, class II, DP beta 1; HLA-DQB1: Major histocompatibility complex, class II, DQ beta 1; HLA-DRA: Major histocompatibility complex, class II, DR alpha; HLA-DPA1: Major histocompatibility complex, class II, DP alpha 1; BDCA-4: Neuropilin 1; T-bet: T-box transcription factor 21; STAT4: Signal transducer and activator of transcription 4; STAT1: Signal transducer and activator of transcription 1; IFN-γ: Interferon gamma; TNF-α: Tumor necrosis factor; GATA3: GATA binding protein 3; STAT6: Signal transducer and activator of transcription 6; STAT5A: Signal transducer and activator of transcription 5A; IL13: Interleukin 13; BCL6: BCL6 transcription repressor; IL21: Interleukin 21; IL17A: Interleukin 17A; FOXP3: Forkhead box P3; CCR8: C-C motif chemokine receptor 8; STAT5B: Signal transducer and activator of transcription 5B; TGFβ: Transforming growth factor-beta; PD-1: Programmed cell death 1; CTLA4: Cytotoxic T-lymphocyte associated protein 4; LAG3: Lymphocyte activating 3; TIM-3: Hepatitis A virus cellular receptor 2; GZMB: Granzyme B; Tfh: Follicular helper T.