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Sortilin deficiency does not impact Lp(a) clearance in mice. Purified human Lp(a) (25 μg) was injected into the tail vein of male and female wild-type or Sort1-/- mice. Blood was samples at the indicated times and plasma Lp(a) was measured by ELISA. No significant differences in residual Lp(a) levels between Sort1+/+ and Sort1-/- animals (sexes considered separately) were observed at any time point. Lp(a), lipoprotein(a).
