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. 2022 May 1;12(8):3758–3775. doi: 10.7150/thno.71722

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Genome-wide transcriptome analyses of mouse models (UUO) of fibrosis. A. UUO mice renal cortices were cut with laser capture microdissection (Thermo Scientific) to obtain renal tubules. GO term analysis of the number of genes that differed between the sham and UUO kidney tissue in different pathways. B. Heatmap analysis of the expression of transcripts related to fatty acid metabolism. C. Protein-protein interaction network of differentially expressed genes. Network nodes represent proteins, blue and red nodes represent down- and up-regulated genes, and lines indicate protein-protein associations. D. Gene set enrichment analysis highlighting strong enrichment for the FAO pathway in samples obtained from the kidneys of mice with UUO.