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. 2022 May 9;12(8):3862–3881. doi: 10.7150/thno.70951

Figure 2.

Figure 2

AEVs-Aβ+H ameliorate cognitive behavior deficits and promote synaptic plasticity in APP/PS1 mice. (A) Schedule of intranasal administration and behavior test of APP/PS1 mice. (B) Spontaneous alternation in Y-maze (n = 6-8). (C) The representative movement tracks of escape latency on day 5 in navigation test of MWM. (D-E) The escape latency (n = 8/9). Representative movement tracks in spatial probe test (F), numbers of crossing the removed platform area (G) and time spend in target quadrant (I) in spatial probe test of MWM, n = 8/9. (H) The representative images of synaptic structure in CA1 region of hippocampus observed by TEM. The length (J) and width (K) of PSD were quantified from 7 random fields per slide, 1 slide per animal, and 3 animals per group (n = 21). Data are mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. P values are calculated by one-way ANOVA with Tukey's post-hoc test and two-way ANOVA with Tukey's post-hoc test.