Skip to main content
. 2022 May 9;12(8):3862–3881. doi: 10.7150/thno.70951

Figure 3.

Figure 3

AEVs-Aβ+H enhance the expression of synaptic proteins and alleviate brain Aβ burden in APP/PS1 mice. (A-H) The expression of PSD95, GAP43 and SYN in the prefrontal cortex (PFC) (A) and hippocampus (E) of APP/PS1 mice with intranasal administration of AEVs. The relative expression quantification of PSD95 (B), GAP43 (C), SYN (D) in the PFC and PSD95 (F), GAP43 (G), SYN (H) in hippocampus, n = 8-10. (I) The representative images of Aβ plaque in the dentate gyrus (DG), CA1 and CA3 regions of hippocampus (Scale: 100 µm). (J-L) The area of Aβ plaque is analyzed by image-pro plus software, n = 5-7. (M) Aβ in the PFC and hippocampus were detected by western blot. The quantified expression of Aβ in the PFC (N) and hippocampus (O), n = 8-10. Data are mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. P values are calculated by one-way ANOVA with Tukey's post-hoc test.