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. 2022 May 9;12(8):3862–3881. doi: 10.7150/thno.70951

Figure 6.

Figure 6

miR-206-3p antagomirs alleviate learning and memory deficits in AD mice. (A) Schematic protocol for the hippocampal injection of miR-206-3p antagomirs and behavior test. (B-C) miR-206-3p level in the PFC (B, n = 4) and hippocampus (C, n = 6) of AD mice with brain injection of miR-206-3p antagomirs. (D) The representative movement tracks of escape latency on day 5 in navigation test of MWM. (F) The escape latencies of mice. Representative movement tracks in spatial probe test (E), numbers of crossing the removed platform area (G) and time spend in target quadrant (H) in spatial probe test of MWM, n = 9/10. (I) Spontaneous alternation in Y-maze, n = 9-12. The expression of PSD95, GAP43 and SYN in the PFC (J-M) and hippocampus (N-Q) of AD mice with brain injection of miR-206-3p antagomirs and antagomir NC, n = 8/9. Data are mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. P values are calculated by one-way ANOVA with Tukey's post-hoc test and two-way ANOVA with Tukey's post-hoc test.