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. 2022 May 9;12(8):3862–3881. doi: 10.7150/thno.70951

Figure 8.

Figure 8

AEVs-Aβ+H and miR-206-3p antagomirs increase BDNF levels. (A) Potential binding sites in 3'UTR of BDNF. (B) Identification of miR-206-3p potential binding sites to BDNF 3'UTR performed by luciferase reporter assay, n = 4. (C-D) The expression of BDNF in rat primary cortical neurons transfected with miR-206-3p mimics and inhibitors, n = 4. (E-G) BDNF expression in the PFC and hippocampus of APP/PS1 with intranasal administration of AEVs, n = 8-10. (H-J) The expression of BDNF in the PFC and hippocampus of AD mice with hippocampal injection of miR-206-3p antagomirs and antagomir NC, n = 8/9. (K-M) The level of AEP (full-length and cleaved AEP) in the PFC and hippocampus of APP/PS1 mice with intranasal administration of AEVs, n = 8-10. (N-P) The level of AEP (full-length and cleaved AEP) in the PFC and hippocampus of AD mice with hippocampal injection of miR-206-3p antagomirs, n = 11/12. Data are mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. P values are calculated by one-way ANOVA with Tukey's post-hoc test.