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. 2022 Apr 24;12(8):3584–3600. doi: 10.7150/thno.72192

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Schematic representation of TRIB1 mediated TAM regulation. Alteration of TRIB1 distinctly regulates TAMs to enhance tumor growth. Reduction of TRIB1 accelerates oncogenic cytokine IL-6, IL-10, CCL20, PD-L1, and VEGF expressions in TAMs which take part in the inhibition of cell apoptosis, immune cell dysfunction, angiogenesis, and develop resistance to therapies. Whilst the overexpression inhibits pro-inflammatory TAM in the TME to suppress the immune response and enhance cancer cell survival. TRIB1 conversely influence IL-15 expression, which reduces T cell infiltration and potentially disrupts T cell-induced immune responses.