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Characterization of nano-formulations. (A) TEM images of (a) DIV (∼7 % theoretical LC of DOX·HCl), (b) DC-DIV/C and (c) D-DIV/C (∼20 % theoretical LC of DOX·HCl), all scale bars are 0.2 µm; CLSM images of (a′) DIV (∼7 % theoretical LC of DOX·HCl), (b′) DC-DIV/C and (c′) D-DIV/C (∼20 % theoretical LC of DOX·HCl). (B) In vitro drug release profiles of (a) DC-DIV and (b) DC-DIV/C at pH 7.4 and 5.5.
