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. 2022 May 13;12(8):3977–3994. doi: 10.7150/thno.70852

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Cellular uptake of DOX·HCl and uptake synchronism in doxorubicin-resistant cells. (A-B) DOX·HCl cellular accumulation in MCF-7/ADR (A) and K562/ADR (B) cells at different points were quantitatively determined by flow cytometry. The concentration of DOX·HCl and CQ in these various groups were 5 µg/ml and 10 µg/mL, respectively. (C-D) Synchronization coefficient (the ratio of DOX·HCl / CQ) exhibited by (C) MCF-7/ADR cells and (D) K562/ADR cells. (*p<0.05, **p<0.01, ***p<0.001, mean ± SD, n =3).