. 2022 May 13;12(8):3977–3994. doi: 10.7150/thno.70852

Table 1.

Pharmacokinetic parameters after intravenous administration of DC, D-DIV/C and DC-DIV/C at 5 mg/kg DOX·HCl or with 10 mg/kg CQ in rats (n = 3, mean ± SD).

Treatment	Drug measured	Pharmacokinetic parameters
Treatment	Drug measured	t_1/2α^a (h)	t_1/2β^b (h)	AUC^c (μg·h/mL)	CL^d (L/h/kg)	MRT^e (h)
DC	DOX·HCl	0.03 ± 0.01	4.52 ± 0.58	1.03 ± 0.19	3.29 ± 0.48	4.17 ± 0.76
DC	CQ	0.22 ± 0.07	7.50 ± 1.51	3.28 ± 0.39	1.53 ± 0.22	8.03 ± 1.50
D-DIV/C	DOX·HCl	0.22 ± 0.09	37.72 ± 8.74	13.56 ± 0.49	0.27 ± 0.03	47.94 ± 12.81
DC-DIV/C	DOX·HCl	0.26 ± 0.17	33.70 ± 16.02	12.62 ± 2.12	0.28 ± 0.05	47.57 ± 22.68
DC-DIV/C	CQ	0.96 ± 0.50	35.89 ± 6.53	21.33 ± 0.66	0.19 ± 0.01	45.08 ± 6.88

^at1/2α: distribution half-life;^bt1/2β: elimination half-life; ^cAUC: area under the plasma concentration-time curve; ^dCL: total body clearance; ^eMRT: mean residence time.