Figure 7.

In vivo biocompatibility of the 9T-PUNNC. (A) PLT and WBC counts of mice treated with PBS or the 9T-PUNNC for different times (n = 3). (B) Measurement of the levels of AST and ALT of mice treated with PBS or the 9T-PUNNC for different times (n = 3). (C) Biodistribution of the 9T-PUNNC in various organs and tumor tissues of nude mice after different exposure times. (D-F) RT-PCR analysis of the expression of ER stress response-related genes for main organs from mice treated with PBS or 9T-PUNNC for 120 h: (D) spleen, (E) lungs, and (F) kidneys, respectively. (G) Histological sections of main organs (heart, liver, spleen, lungs, and kidneys) obtained from PBS or 9T-PUNNC-treated mice. Scale bar, 50 µm. Statistical analysis was performed using the unpaired Student's t-test (P > 0.05).