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. 2022 May 9;12(8):3928–3945. doi: 10.7150/thno.70762

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The expression level of 5-HT2B positively correlates with disease prognosis. (A) Distribution of 5-HT2B expression (high, 7-9; moderate, 4-6; low, 1-3; no, 0) in normal (n = 271) or CRC (n = 292) specimens from humans. (B) The 5-year survival rate of CRC patients with different 5-HT2B expression levels in 191 colorectal cancer specimens. (C) Immunohistochemical analysis of 5-HT2B, cyclin D1, and p21 in CRC tissue with high or low expression of 5-HT2B. (D-F) The positive cell percentages of 5-HT2B (D), cyclin D1 (E), and p21 (F) in CRC tissues with high (n = 5) and low (n = 15) expression of 5-HT2B. Scale bars, 100 μm. Error bars represent the mean ± SEM. ns: not significant, ^*P < 0.05, ^***P < 0.001; log-rank test (B) and unpaired Student's t-test (D-F).