FIG. 3.

Summary of correlations between cognitive testing, treatment, structural, functional, and effective connectivity at Time 2. Correlations for the breast cancer group for FA and EB, therapy, and cognitive deficits are linked to form a network that may inform future interventions. Negative correlations are denoted by the minus (−) sign. Bilateral superior and left medial orbital frontal are part of the OPFC. Red box denotes left hemisphere and blue denotes right hemisphere structures. Dash line box demotes structures associated with the PMN. (A) Denotes correlations between brain regions associated with changes in cognitive testing. (B) Additional connections associated with HRM form circuits with structures linked to the OPFC and PMN. (C) Associations with RAD further consolidate the interactions between treatment, connectivity, and the OPFC and PMN. (D) The number of chemotherapy cycles (Cyc) has a positive association with the OPFC and may represent an unidentified association between anthracyclines and strengthening of maladaptive networks. COWA, Controlled Oral Word Association; HRM, hormone blockade therapy; OPFC, orbital prefrontal cortex; RAD, radiation dose. Color images are available online.