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. 2022 May 6;61(20):7729–7745. doi: 10.1021/acs.inorgchem.1c03957

Table 3. IC50 Determination of C7, C8 Complexes and Cisplatin after 72 h (24 h Internalization) in Light and Dark in HeLa, A2780, and A2780cis Cells.

      IC50 (μM)
 
entry complex cell line lighta dark PI
1 C7 HeLa 4 ± 3 >200 >50
2 C7 A2780 1.4 ± 0.8 18 ± 9 13
3 C7 A2780cis 2.7 ± 0.7 19 ± 8 7
4 C8 HeLa >50 >200 n.d.
5 C8 A2780 5 ± 3 >200 >40
6 C8 A2780cis 48 ± 22 >200 4
7 cisplatin HeLa 15.5 ± 3.4 14.7 ± 2.6  
8 cisplatin A2780 2.3 ± 0.3 2.8 ± 0.2  
9 cisplatin A2780cis 15.1 ± 1.5 13.8 ± 0.2  
a

λexc = 450 nm and dose ca. 32 J/cm2. PI = photoactive index (obtained by dividing the baseline IC50 value by the photoactivated IC50 value).