Table 3. IC50 Determination of C7, C8 Complexes and Cisplatin after 72 h (24 h Internalization) in Light and Dark in HeLa, A2780, and A2780cis Cells.
| IC50 (μM) |
|||||
|---|---|---|---|---|---|
| entry | complex | cell line | lighta | dark | PI |
| 1 | C7 | HeLa | 4 ± 3 | >200 | >50 |
| 2 | C7 | A2780 | 1.4 ± 0.8 | 18 ± 9 | 13 |
| 3 | C7 | A2780cis | 2.7 ± 0.7 | 19 ± 8 | 7 |
| 4 | C8 | HeLa | >50 | >200 | n.d. |
| 5 | C8 | A2780 | 5 ± 3 | >200 | >40 |
| 6 | C8 | A2780cis | 48 ± 22 | >200 | 4 |
| 7 | cisplatin | HeLa | 15.5 ± 3.4 | 14.7 ± 2.6 | |
| 8 | cisplatin | A2780 | 2.3 ± 0.3 | 2.8 ± 0.2 | |
| 9 | cisplatin | A2780cis | 15.1 ± 1.5 | 13.8 ± 0.2 | |
λexc = 450 nm and dose ca. 32 J/cm2. PI = photoactive index (obtained by dividing the baseline IC50 value by the photoactivated IC50 value).