Table 2:
Pearson Chi-Square Test Results of Significant mtDNA Variants in Low- and High-responders.
| Position | Amino Acid Change | Gene | Gene Type | Alternate Codon | Alternate Amino Acid | European Haplogroup Marker(s) | Variants in low-responders (out of 15) | Variants in high-responders (out of 15) | Sig. p-value |
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| 185 | G to A | HV2 | D-loop | N/A | N/A | N/A | 6 | 0 | 0.017 |
| 228 | G to A | HV2 | D-loop | N/A | N/A | N/A | 5 | 0 | 0.042 |
| 295 | C to T | HV2 | D-loop | N/A | N/A | J | 5 | 0 | 0.042 |
| 462 | C to T | HV3 | D-loop | N/A | N/A | J | 5 | 0 | 0.042 |
| 489 | T to C | HV3 | D-loop | N/A | N/A | J | 5 | 0 | 0.042 |
| 4215 | T to C | ND1 | Protein coding | N/A | N/A | N/A | 8 | 1 | 0.014 |
| *10397 | A to G | ND3 | Protein coding | TAA | Stop | N/A | 5 | 0 | 0.042 |
| 11250 | A to G | ND4 | Protein coding | N/A | N/A | N/A | 8 | 1 | 0.014 |
| 13707 | G to A | ND5 | Protein coding | N/A | N/A | N/A | 5 | 0 | 0.042 |
| 14797 | T to C | CYTB | Protein coding | N/A | N/A | N/A | 5 | 0 | 0.042 |
| 15451 | C to A | CYTB | Protein coding | N/A | N/A | N/A | 8 | 1 | 0.014 |
| 16068 | C to T | HV1 | D-loop | N/A | N/A | N/A | 5 | 0 | 0.042 |
| 16125 | T to C | HV1 | D-loop | N/A | N/A | N/A | 8 | 1 | 0.014 |
13 positions were significantly different across the mitochondrial genome between the low- and high responders based on variant frequency (p < 0.05).
Asterisk (*) indicates a nonsynonymous position.