Figure 1.

Overview of existing methods for the N-allylation of alkylamines. (a) Examples of allylic amine-containing pharmaceuticals; (b) selected examples of transition-metal-catalyzed N-allylic alkylation using activated allylic substrates; (c) selected examples of transition-metal-catalyzed N-allylation of alkylamines for the synthesis of linear allylic amines using allylic alcohols as allyl sources; (d) existing enzymatic routes for the synthesis of allylic primary amines; and (e) proposed enzymatic routes to accessing secondary and tertiary allylic amines described in this work. RedAm, reductive aminase; CAR, carboxylic acid reductase.