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. 2022 May 6;10(20):6794–6806. doi: 10.1021/acssuschemeng.2c01180

Figure 3.

Figure 3

Comparison of structures of AspRedAm in complex with NADP(H) and rasagaline (a)46 and a homology model of pIR23 (b) created using SWISS-MODEL58 and visualized with ChimeraX.59 Essential catalytic residues in AspRedAm include N93, D169, Y177, which are also conserved in closely related fungal homologues. Equivalent positions in pIR23 feature S95 (S, N, or T in other bacterial homologues), D171, and W179 (W, F, or Y in other bacterial homologues), respectively (Supporting Information Table S3).