Fig. 1.

Study design and work flow. After fulfilling the inclusion criteria (red dashed line box), 92 early multiple sclerosis patients were included for the cortical thickness correlation analysis with HADS-A scores (anxiety symptoms) to generate an anxiety-related atrophy map. Next, atrophy network mapping was applied to project this atrophy map onto a normative functional brain network (n = 1000). As a result, we were able to determine brain regions functionally connected to the atrophied location