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. 2022 May 25;20:189. doi: 10.1186/s12916-022-02391-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Distinct distribution of EZH2 and ADAM12 in human placental villi. A, B Immunofluorescent staining showed that EZH2 (red) was localized mainly in the cytotrophoblast (CTB) but not the syncytiotrophoblast (STB) which was stained for 11β-HSD2 (green) at both early and term pregnancies. Nuclei were counterstained blue with DAPI. Immunohistochemical staining revealed a similar distribution pattern of EZH2. C, D Immunofluorescent staining showed that ADAM12 (green) was mainly localized in the syncytiotrophoblast (STB) and to a much lesser extent in the cytotrophoblast (CTB) at both early and term pregnancies. Nuclei were counterstained blue with DAPI. Immunohistochemical staining revealed a similar distribution pattern ADAM12. Non-immune serum served as negative control (NC). Scale bars, 20 μm